[유기] Study of Bioapplication of Organic Fluorophore - Indolizine-Based Fluorophore(ex: SF) - 읽는중...

03-05 13:14 에 

:Discovery, Understanding, and Bioapplication of Organic Fluorophore: A Case Study with an Indolizine-Based Novel Fluorophore, Seoul-Fluor

 

Eunha Kim,† Youngjun Lee,‡ Sanghee Lee,‡,§ and Seung Bum Park*,‡ † Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, United States ‡ Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Seoul 151-747, Korea (South)

 

 

:Monochromophoric Design Strategy for Tetrazine-Based Colorful Bioorthogonal Probes with a Single Fluorescent Core Skeleton

 

 

이걸 읽고있다!!!!!

 

형광프로브를 연구하기 위해서는 

1. absorption wavelength

2. emission wavelength

3. molar absoptivity 

4. quantum yield

5. 구조적인 형광 발색단 변화의 물리화학적 특성 (physiochemical properties on the basis of structural changes in fluorochrome)

 

이 아쥬 크루시얼 하당. 

 

아그리고 참고로 fluorochrome 또한 분자이므로, inert 하지 않다. 

 

환경에도 영향받고, 다른 biomolecule 과 영향 주고받으며 광특성이 변하기도한다. 따라서 분자크기적 이해가 형광물질 디자인할때 즁요즁요.  

 

 

iedda reaction of tetrazine

 

enamine.net/building-blocks/medchem/view-all/structurally-optimized-tetrazines-for-rapid-biological-labeling

출처 : www.biosynergy.re.kr/newsletter/16/sub0303.html 출처: [BRIC Bio통신원] 생체 탐침의 고효율 형광증폭 기술 개발 ( https://www.ibric.org/myboard/read.php?Board=news&id=291143 ) www.bioin.or.kr/board.do;jsessionid=EA118C91AB22EAD1392BBF92BC6C3B72?num=276744&cmd=view&bid=research&cPage=1&cate1=all&cate2=all2 kosen21.org/about/webzineDetail.do?webzineSeq=WEBZINE_000000000045&cornerSeq=CORNER_0000000000332&quize=N www.bioin.or.kr/board.do;jsessionid=EA118C91AB22EAD1392BBF92BC6C3B72?num=276744&cmd=view&bid=research&cPage=1&cate1=all&cate2=all2